A Holtville man was seriously injured in a Friday morning traffic accident.

According to the California Highway Patrol, 65-year-0od Jose Cardenas Melendrez was southbound on State Route 111 north of Harris Road. A semi-truck with attached trailer was parked on the right shoulder of the highway with Luis Manuel Ramirez Leal, 44, of Mexicali, in the cab. According to the CHP, for an unknown reason, Melendrez veered onto the shoulder of the road and ran into the rear of the big rig. Melendrez sustained major injuries and was flown to Desert Regional Medical Center by REACH air ambulance. Leal was not injured. The crash remains under investigation.